Sunday, 10 June 2018

Medical Abortion in Very Early Pregnancy


Despite the availability of highly effective contraceptive methods, approximately 50% of pregnancies are not planned, and about half of these are terminated.For a long time, surgical methods of pregnancy termination were available: sharp or suction curettage in the first trimester of gestation, and dilatation and evacuation in the second trimester. Subsequently, medical options that interfere with the progesterone support (mifepristone) and induce uterine contractions (misoprostol) became available. Various doses, combinations, and routes of administration are in use. The efficacy of these medical options has been proven up until 9 weeks' gestation, and their use has been increasing.Typically, before prescribing one of these medications, ultrasound is used to confirm the intrauterine location of the pregnancy, and laboratory or ultrasound follow-up is performed to document the completeness of the process.
In many cases, however, a decision to abort the pregnancy is made at a very early stage, when ultrasound cannot yet detect the pregnancy. The efficacy of medical options in very early pregnancy has not been well studied. A recent systematic review evaluated the efficacy of medical abortion before 42 days of gestation.

Systematic Review Findings

The review summarizes the findings of six randomized controlled trials (RCTs) and nine prospective observational studies of mifepristone and misoprostol use for medical abortion. There is considerable heterogeneity with respect to the dose of mifepristone (50 mg-600 mg) or misoprostol (200 µg-800 µg) used and the route of misoprostol administration (oral, buccal, vaginal). The primary outcome in these studies was successful abortion (defined as no need for surgical procedures).
The pooled estimate of unsuccessful medical abortion was 0.02 (95% confidence interval [CI], 0.01-0.03) in the RCTs and 0.04 (95% CI, 0.03-0.06) in the observational studies. When the efficacy of medical abortion up to 42 days gestation was compared with that of medical abortion between days 43 and 49, no significant difference was found (RCTs: odds ratio [OR], 0.51; 95% CI, 0.21-1.27; observational studies: OR 0.9; 95% CI: 0.6-1.33). The investigators concluded that mifepristone and misoprostol provide effective medical abortion for very early pregnancies (up to 42 days).

Viewpoint

Following successful fertilization and embryo cleavage, most blastocysts implant in the uterine cavity. In 1%-2% of pregnancies, however, the implantation occurs in extrauterine locations. Most clinically diagnosed pregnancies progress normally, but 15%-25% are miscarried, mostly as a result of random genetic errors.In the case of intrauterine implantation around week 5 of gestation, the sac can be visualized. If pregnancy is not desired, termination involves a choice between surgical and medical methods. The decision is less obvious when the sac cannot yet be visualized and its intrauterine location cannot be confirmed.
Under well-controlled conditions using sedation and appropriate pain control, surgical termination of pregnancy is associated with minimal bleeding or pain. However, it can be associated with surgical complications (trauma, heavier bleeding, infection), which can lead to further interventions.
Medical abortion can be more painful because the products of conception have to be expelled from the uterus, and it is accompanied by prolonged bleeding. Still, medical abortion obviates surgical complications and is significantly cheaper.
This study showed that medical abortion is effective even in very early pregnancy, when the location of the pregnancy cannot be confirmed by ultrasound. Therefore, there is no need to delay the intervention. Compared with a later stage of pregnancy, medical abortion at an earlier stage may cause less pain and bleeding. Home use may be considered. Appropriate patient selection (no increased risk for or symptoms of ectopic pregnancy, appropriate follow-up to confirm successful abortion, patient compliance) is obviously important
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Tuesday, 22 May 2018

How does being overweight affect fertility?


How does being overweight affect fertility?

May 22, 2018
by Karin Hammarberg, The Conversation
How does being overweight affect fertility?
Diet and exercise are more likely to succeed when done together. Credit: www.shutterstock.com
The proportion of Australians who are overweight or obese is at an all-time high. We know excess weight is linked to many adverse health consequences, but there is now growing understanding that it also affects fertility.
Excess weight affects female fertility
A fine  regulates the menstrual cycle. Overweight and obese  have higher levels of a hormone called leptin, which is produced in fatty tissue. This can disrupt the hormone balance and lead to reduced fertility.
The quantity and distribution of body fat affect the menstrual cycle through a range of hormonal mechanisms. The more  and the more abdominal fat, the greater the risk of fertility difficulties.
Excess weight, particularly excess abdominal fat, is linked to insulin resistance (when the body has to produce more insulin to keep blood sugar levels normal) and decreased levels of sex hormone-binding globulin (SHBG), a protein that is involved in the regulation of the sex-hormones androgen and oestrogen.
This increases the risk of , which in turn reduces fertility. One study found women who were obese were much less likely to conceive within one year of stopping contraception than women in the normal weight range (66.4% of obese women conceive within 12 months, compared with 81.4% of women of normal weight).
Changes in the fine-tuned hormonal balance that regulates the menstrual cycle triggered by excess weight and obesity also increase the risk of anovulation (when no egg is released by the ovaries). Women with a body mass index (BMI) above 27 are three times more likely than women in the normal weight range to be unable to conceive because they don't ovulate.
Many women who carry excess weight still ovulate, but it appears the quality of the eggs they produce is reduced. The evidence for this is that among women who ovulate, each unit of BMI above 29 reduces the chance of achieving a pregnancy within 12 months by about 4%.
This means that for a woman with a BMI of 35, the likelihood of getting pregnant within a year is 26% lower, and for a woman with a BMI of 40 it is 43% lower compared with women with a BMI between 21 and 29.
And when couples use IVF to conceive, the chance of a  is lower for women who are overweight or obese than for women with normal BMI. On average, compared to women in the healthy weight range, the chance of a live birth with IVF is reduced by 9% in women who are overweight and 20% in women who are obese .
Excess weight affects male fertility
In men, obesity is also associated with lower fertility. This is likely due to a combination of factors. These include hormone problems, sexual dysfunction and other health conditions linked to obesity such as type 2 diabetes and sleep apnoea (which are both associated with lowered testosterone levels and erectile problems.
review of studies on the effects of paternal obesity on reproductive outcomes found obese men were more likely to experience infertility and less likely to have a live birth if they and their partner used assisted reproduction technology (ART) such as IVF.
This is thought to be because obesity not only reduces sperm quality, it also changes the physical and molecular structure of sperm cells.
The good news
While the facts about obesity and fertility can seem daunting, there is some good news too. Weight-loss interventions, particularly those that include both diet and exercise, can promote  regularity and improve the chance of pregnancy. In  with anovulatory infertility, even a modest weight loss of 5-10% improves fertility and the chance of conceiving.
A weight loss of 7% of body weight and increased physical activity to at least 150 minutes a week of moderate intensity activity is recommended to improve the health and fertility of people who carry excess .
Lastly, men and women are twice as likelyto make positive health behaviour change if their partner does too. So becoming pregnant will be more likely if you diet and exercise together.
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Monday, 30 April 2018

RESIST UNSAFE BACKSTREET ABORTIONS!!!


The Impact of Illegal Abortion..RESIST!



  • Excessive bleeding
  • Chronic and acute infections
  • Intense pain
  • Convulsions
  • Shock
  • Coma
  • Life-threatening infections
  • Pelvic inflammatory disease
  • Punctured uterus
  • Infertility
  • Maternal death rates

Every year, worldwide, about 42 million women with unintended pregnancies choose abortion, and nearly half of these procedures, 20 million, are unsafe. Some 68,000 women die of unsafe abortion annually, making it one of the leading causes of maternal mortality (13%). Of the women who survive unsafe abortion, 5 million will suffer long-term health complications. Unsafe abortion is thus a pressing issue. Both of the primary methods for preventing unsafe abortion—less restrictive abortion laws and greater contraceptive use—face social, religious, and political obstacles, particularly in developing nations, where most unsafe abortions (97%) occur. Even where these obstacles are overcome, women and health care providers need to be educated about contraception and the availability of legal and safe abortion, and women need better access to safe abortion and postabortion services. Otherwise, desperate women, facing the financial burdens and social stigma of unintended pregnancy and believing they have no other option, will continue to risk their lives by undergoing unsafe abortions.
According to the World Health Organization (WHO), every 8 minutes a woman in a developing nation will die of complications arising from an unsafe abortion. An unsafe abortion is defined as “a procedure for terminating an unintended pregnancy carried out either by persons lacking the necessary skills or in an environment that does not conform to minimal medical standards, or both.” The fifth United Nations Millennium Development Goal recommends a 75% reduction in maternal mortality by 2015. WHO deems unsafe abortion one of the easiest preventable causes of maternal mortality and a staggering public health issue.

Resist Avoidable Deaths.
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0706666542


Friday, 27 April 2018

What Are Menstrual Cramps?


Having menstrual cramps is one of the most common, annoying parts of your period. They can strike right before or during that time of the month. Many women get them routinely.
You’ll feel these cramps in your lower belly or back. They can range from mild to severe. They usually happen for the first time a year or two after a girl first gets her period. With age, they usually become less painful and may stop entirely after you have your first baby.
Your doctor may call your cramps “dysmenorrhea.”

Symptoms

Chances are, you know all too well how it feels. You may have:
  • Aching pain in your belly (sometimes severe)
  • Feeling of pressure in your belly
  • Pain in the hips, lower back, and inner thighs
When cramps are severe, symptoms may include:
  • Upset stomach, sometimes with vomiting
  • Loose stools


What Causes Them

Menstrual cramps happen because of contractions in the uterus, or womb, which is a muscle. If it contracts too strongly during your menstrual cycle, it can press against nearby blood vessels. This briefly cuts off the supply of oxygen to the uterus. It’s this lack of oxygen causes your pain and cramping.

What You Can Do

If you have mild menstrual cramps, take aspirin or another pain reliever, such as acetaminophen, ibuprofen, or naproxen. For best relief, you must take these medications as soon as bleeding or cramping starts.
Heat can also help. Place a heating pad or hot water bottle on your lower back or tummy. Taking a warm bath may also provide some relief.
You should also:
  • Rest when needed.
  • Avoid foods that contain caffeine and salt.
  • Not use tobacco or drink alcohol.
  • Massage your lower back and abdomen.
Women who exercise regularly often have less menstrual pain. To help prevent cramps, make exercise a part of your weekly routine.
If these steps do not relieve pain, tell your doctor, in case you need medicines such as:
  • Ibuprofen (higher dose than is available over the counter) or other prescription pain relievers
  • Hormonal drugs 


Secondary Dysmenorrhea

Primary dysmenorrhea means that your cramps are due to your cycle. Secondary dysmenorrheais the term your doctor may use if you have a problem in your reproductive organs that causes your cramps. Several conditions can cause it:
  • Endometriosis is a condition in which the tissue lining the uterus (the endometrium) is found outside of the uterus.
  • Pelvic inflammatory disease (PID) is an infection caused by bacteria that starts in the uterus and can spread to other reproductive organs.
  • Stenosis (narrowing) of the cervix , which is the lower part of the uterus, can be caused by scarring, as well as a lack of estrogen after menopause.
  • The inner wall of the uterus may have fibroids (growths).

When to Call a Doctor

If you have severe or unusual menstrual cramps, or cramping that lasts for more than 2 or 3 days, tell your doctor. Menstrual cramps, whatever the cause, can be treated, so it's important to get checked.
If it turns out that your cramps aren’t due to your period, you might need other tests to find the right treatment.

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Uteroplacental blood flow assessment



Uteroplacental blood flow assessment is an important part of fetal well-being assessment and evaluates Doppler flow in the uterine arteries and rarely the ovarian arteries.

Pathology

In a non-gravid state and at the very start of pregnancy the flow in the uterine artery is of high pulsatility with a high systolic flow and low diastolic flow. A physiological early diastolic notch may be present.
Resistance to blood flow gradually drops during gestation as a greater trophoblastic invasion of the myometrium takes place. An abnormally high resistance can persist in pre-eclampsia and IUGR. If resistance is low, it has an excellent negative predictive value with a less than 1% chance of developing either pre-eclampsia or having IUGR . A high resistance often equates to a 70% chance of pre-eclampsia and 30% chance of IUGR.

Radiographic features

Ultrasound
The parameters used in the assessment of uteroplacental blood flow include:
  • RI = resistive index
  • PI = pulsatility index
  • presence of persistent diastolic notching
Resistive index (RI)
This is calculated by the following equation:
RI = (PSV-EDV) / PSV = (peak systolic velocity - end diastolic velocity) / peak systolic velocity 
  • normal (low resistance) RI < 0.55
  • high resistance
Pulsatility index (PI)
This is calculated by the following equation:
  • PI = (peak systolic velocity - end diastolic velocity) / time averaged velocity = (PSV - EDV) / TAV
Abnormal patterns include
  • persistence of a high resistance flows throughout pregnancy
  • persistence of notching throughout pregnancy
  • reversal of diastolic flow throughout pregnancy: severe state​

Management of Normal Labour

  • Maximum observation with minimal active intervention.

    Aim:

    Non intereference with watchful expectancy  so  as  to prepare  the  patient  for natural birth.
    To monitor carefully the progress  of  labour, maternal condition and fetal behaviour so as to detect any intrapartum complication early.


    General Principle:

    -Initial assessment
    -Observation and intervention if labour becomes abnormal
    -close monitoring of the fetal  and maternal condition
    -Adequate pain relief
    -Emotional support
    -Adequate hydration

    Initial Assessment:

    - Detailed History
    - Clinical Examination
    - Basic investigation
    Aim:
     - To identify as high risk before the onset of labour


    O/E:
    Vitals 
    General sign
    Chest/CVS

    P/A:
    Fundal Height
    Lie
    Presentation
    Engagement
    Contraction
    FHS



    V/I:
    P/V:- Dilatation,Effacement,Consistency,Position,Station,
        Membrane Status ,CPD

    Investigation:


    Diagnosis and Confirmation of Labour:

    Admission
    1.Encouragement and Assurance
    2.Maintain cleanliness of women and her enviroment
    3.Rest and ambulation
    4.Diet(Liquid and a few biscuits, I/V fluid)
    5.Bladder(Encourage women to empty regularly)
    6.Bowel(Donot give  enema routinely)
    7.Relief of pain:
     - Suggest change of position
     - Encourage mobility
     - Massage her back
     - Encourage breathing exercise
     - If necessary pethidine 1 mg/kg body weight or morphine 0.1 mg/kg IM
     - Epidural
    8.Assessment of progression of labour by partograph
     - Patient information 
     - FHR every 30 minutes
     - Amniotic fluid:Record the color of amniotic fluid at every P/V.

    I: Membrane intact
    C: Clear fluid
    M:  Meconium stained fluid
    B: Blood stained fluid

    Moulding:

    1.Sutures apposed
    2.Sutures overlapped but reducible
    3.Suture overlapped but not reducible


    Cervix Dilatation:
    -Assess at every vaginal examination and marked with a cross 
    -Begin plotting on the partograph  at 4 cm

    Alert line:
    A line starts at 4 cm of cervical dilatation to the point of expected full dilatation  at the rate of 1 cm/hr.

    Action line: Parallel and 4 hrs to the right of the alert line.
    Descent: Assessed by P/A. Head divided into five parts. Refers to the part of the head palpable above the s.pubis.
    Hours: Refers to the time elapsed since onset of ASOL.
    Time: Record actual time

    Contraction: Chart every half and hourly.Palpate the no.of contraction in every 10 min.and duration in sec.
    < 20 sec: mild
    20-40 sec : moderate
    >40 sec : Strong
    Oxytocin: Amount ofoxytocin/ltr, Drops/min

    • Drugs: Record if additional  drugs given 
    • Pulse: Half hourly
    • B.P: Every 4 hourly
    • Temperature: 2 Hrly
    • Protein,Acetone volume:  Record every time urine is passed

    Protraction - as a slow rate of cervical dilatation or descent
     Primiparas - less than 1.2 cm dilatation per hour or less than 1 cm descent per hour.  
     multiparas - less than 1.5 cm dilatation per hour or less than 2 cm descent per hour.  


       Arrest disorders - as a complete cessation of dilatation or descent. Arrest of dilatation  is defined as 2 hours with no cervical change,  Arrest of descent as 1 hour without fetal descent. 

    SECOND STAGE OF LABOUR

    Progress of second stage of labour:
    1.Increasing intensity of uterine contraction
    2.Appearance of bearing down effort
    3.Urge to defecate with descent of presenting part 
    4.Complete dilatation of cervix as evidenced by P/V

    AIM

    1.To assist in the natural expulsion of the fetus slowly and steadily.
    2.To prevent perineal  injury


    General measures:

    Pt should be in bed
    Constant supervision for progress of fetal  &  maternal  condition.
    Fetal condition:
    If  there  is  FHS  less than 100 or  more than 160 suspect  fetal distress.
    Position & presentation: other than occiput  anterior with well flexed head  are considered malposition.   

    Maternal  conditions:
    Evaluate the women for sign of distress:
    Pulse: If the women’s pulse’s  increased ,she
    may be dehydrated or  in pain.
    BP: If BP decreased suspect APH.
    Acetone: If acetone is present in the
    urine,suspect poor hydration & nutrition and give dextrose IV.

    Preperation for delivary:
     once the cervix is fully
    dilated & the women in expulsive
    phase,encourage  to assume  position she
    prefers & encourage to push.
    • Clean hand:
    • Clean surface:
    • Clean cutting & ligating of the cord:

    Delivery of Head
    • Ask the women to pant or give only small pushes with contractions as the baby’s head delivers.
    • To control birth of the head, place the fingers of one against the baby’s head to keep it flexed(bent).
    • Continue to gently support the perineum as the baby’s head delivers.
    • Once the baby’s head delivers, ask the women not to push.
    • Suction the baby’s mouth and nose.



    Feel around the baby’s neck for the umbilical cord:
        - If the cord is around the neck but is loose,slip it over the baby’s head;
        - If the cord is tight around the neck,doubly clamp and cut it before unwinding it from around the neck.
     Hooking the fingers in the axillae should be avoided  - injure the nerves of the upper extremity, producing a transient or possibly even a permanent paralysis. 
      Immediately after delivery of the newborn, there is usually a gush of amnionic fluid, often tinged with blood but not grossly bloody.

    Delivery of shoulder
    Completion of delivery


    Clamping the Cord
    The umbilical cord is cut between two umbilical cord clamps –
      -  one clamp at 4 to 5 cm from the fetal abdomen,  
      -  other clamp at 2 to 3 cm from the fetal abdomen.  

    Timing of Cord Clamping
    If after delivery, the newborn is placed at or below the level of the vaginal introitus for 3 minutes and the fetoplacental circulation is not immediately occluded by clamping the cord, an average of 80 mL of blood may be shifted from the placenta to the neonate.
      This provides about 50 mg of iron, which reduces the frequency of iron deficiency anemia later in infancy.
        The risk of circulatory overloading from gross hypervolemia is high, especially in preterm and growth-retarded neonates.
      


    Management of the Third Stage of Labor

    Immediately after delivery of the newborn, the size of the uterine fundus and its consistency are examined.
     If the uterus remains firm and there is no unusual bleeding, watchful waiting until the placenta separates is the usual practice. 
    Massage is not employed, but the fundus is frequently palpated to make certain that the organ does not become atonic and filled with blood from placental separation.
    When the placenta has separated, it should be determined that the uterus is firmly contracted.
     The mother may be asked to bear down, and the intra-abdominal pressure may be adequate to expel the placenta. 
    If these efforts fail, or if spontaneous expulsion is not possible,  then after  pressure is exerted with the hand on the fundus to propel the detached placenta into the vagina 


    FOURTH  STAGE:  usually about 1-2 hrs after delivery

    Vital signs
       BP , Pulse
      Full Bladder
      Trauma
      Uterine  Relaxation / Atony
      Sudden Collapse / Shock
     
    VULVAL HAEMATOMA / RUPTURED UTERUS
    pains -  Analgesia if needed
     
    Transfer to inpatient if all signs are normal

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0753321312

ANTENATAL CARE




Case: A 35 year old lady G4 P2 A1 comes to you for the first time for her pregnancy check up. She does not clearly remember her LMP. She says she hasn’t been menstruating for a few months. On PA examination you find uterus palpable 4cm above the pubic symphysis. What would you like to do the next?

What  is antenatal care ?
Why is it important , what is the aim  of doing ANC?
What do we do in antenatal care?

Definition

It is the clinical assessment and care  of mother and fetus during pregnancy for the purpose of obtaining the best possible outcome for both mother and child

Ideal situation

Women to be seen prepregnancy, take advise offered and enter pregnancy in optimum health and mental condition
                                            |
Early booking, adequate ANC visits, recognition and management of complications
                                            |
Normal vaginal delivery
                                            |
Healthy baby and healthy mother

AIM
  • To promote ,protect and maintain the health of the mother during pregnancy
  • To detect high risk cases and give them special attention
  • To forsee complications and manage them
  • Maternal education regarding elements of child care, nutrition, personal hygiene , birth preparedness
  • To remove anxiety and fear associated with pregnancy and childbirth

Decrease the maternal and infant mortality




Ensure that the whole pregancy and childbirth is a happy and fruitful  experience

What do we do in ANC ?
  • EVALUATE : history, examination, investigations

  • RECOGNIZE /ADVICE / TREAT
          recognize complications,
          give advice /educate mother,
          treat  complications , treat specific 
           conditions, supplement deficiencies etc

Women comes to hospital

DETAILED HISTORY

     Identification, education, occupation 
      Menstrual history : LMP
      calculate her POG and EDD (Naegeles formula: 9months +7 days from the first day of LMP)

      Presenting complaint : early/late pregnancy
      Obstetric History: Parity,gravida,year of birth, spacing, abortions, ANC ,labour , delivery and outcome of each preceding pregnancy in detail
      G        P        A           L

      Contraception used
      

Booking visit

Medical history : HTN, DM,Anaemia,bleeding disorders,Heart disease etc
Surgical history : any previous surgery on uterus eg myomectomy,pelvic surgery,VVF repair 
Family History: congenital anomalies,inherited disorders , twinning, HTN,DM etc
Personal history : allergies, diet, smoking , drugs and alcohol intake 

EXAMINATION
GENERAL EXAMINATION
      height, weight , nutrition status
       vitals
      Pallor,oedema,jaundice
      Neck
 CHEST EXAMINATION 
     Lung, Heart
    breast examination

OBSTETRIC EXAMINATION
      
PA: size of uterus (corresponding or not with POG) ,diagnose pregnancy, any scar
      If 20 weeks and more, palpate fetal parts, FHS

      
PS : examine cervix/vagina

      
PV: to diagnose pregnancy, size of uterus, exclude any other pelvic pathology , pelvic size  assessment not done at this time
      

INVESTIGATION
     
Blood : Hgb, ABO and Rh
                  blood sugar /OGT esp in high risk cases
                  VDRL, HBsAg, HIV
      Urine : routine
      Stool : routine
      USG : bleeding PV,not sure of dates,previous history of nonviable fetus, twin history,disparity between POG and clinical assessment
                    

Subsequent visits
  • Monthly till 28 weeks, then 2 weekly till 36 weeks and then weekly till delivery
  • History: Fetal movement, danger symptoms and signs   ( bleeding PV, pain abdomen, persistent headache, persistent vomiting, leaking PV, marked swelling of hands and legs)
  • EXAMINATION: weight, BP ,pallor , edema ,Obstetric examination : SFH , lie, presentation, FHS , engagement etc as the pregnancy advances

PV : after 37 weeks to assess the size of the pelvis, assess cervix (bishops scoring) if planning induction.
INVESTIGATION
        Urine alb and sugar at every visit
        Blood sugar after 28 weeks
        Anti D titre in case RH negative at 28 and 36
        weeks
         USG at 16-20 weeks

INTERVENTION
    * check all investigations and treat accordingly
    * maintain record at every visit : ANC card
    * Supplementation
       i) Iron : 60mg of elemental iron (ferrous sulphate tabs) daily, start after 20 weeks   
       anaemia is  very common in pregnancy
       symptomless
       easily correctable 
       adverse effect on fetus   
ii) folic acid supplementation : 500 microgram daily also to combat anaemia
iii) calcium : 1000mg /daily
iv) vitamins : vit C 50mg/day, thiamine, riboflavin , vit B 12 etc
* Immunization:  to prevent neonatal tetanus with 2 doses of 0.5ml adsorbed TT injection 
      first dose at 16-20weeks and the second dose  after 4 weeks
     if already immunized then single booster dose can be given

* Reinforce advice on nutrition ,personal care and hygiene, FP (Family Planning) method usage, Fetal movement
     As the pregnancy reaches term ,advise regarding signs  of labor, symptoms of complications , birth preparedness
* Referral in case of anticipated complications where facilities are not available
* Special attention to high risk cases

High risk cases

Elderly primi (> 35 years),grand multipara (>5 births)
APH (Antepartum hemorrhage)
PIH (Pregnancy Induced Hypertension)
Malpresentation
Anaemic
Twins
Previous LSCS
Previous SB (Still birth), IUFD (Intrauterine Fetal Death), MTP (Medical Termination Of Pregnancy)
Associated any medical conditions

Simple advises

Diet : increased demand of pregnancy
     Daily calorie requirement :
       2200KC nonpregnant state
       2500KC in pregnancy
       2900KC during lactation
The diet should be healthy and nutritious, affordable and should contain protein (55g/day)and also include milk(1/2 liter to 1 liter /day) ,vitamins ,plenty of water, green leafy vegetables, fruits and nuts.
Help to achieve adequate weight gain ~12 kg

Personal hygiene
Activity   : can do all normal activities,avoid hard work towards the end of pregnancy
Adequate rest with 8hrs sleep at night and 2
     hr rest in day time
Preventing constipation: plenty of fluids, fibre in diet , try and avoid laxatives
Care of teeth, breast 
Coitus : preferably avoided in first trimester and in the last 6 weeks 

Smoking : to be avoided 
       risk of LBW, hypoxia in fetus
Alcohol : to be avoided as increased risk of teratogenicity, spontanous abortion, MR (Mental Retardation) , IUGR (Intra-uterine Growth Retardation)
Drugs: to avoid use of any drugs in pregnancy specailly those that are teratogenic eg gentamycin, sodium valprotae, tetracycline, LSD etc . To change to safer alternatives in case of any medical conditions needing treatment
Avoid Radiation of any kind

Conclusion
  • ANC is an integral part of maternal and fetal health helping to ensure that the mother and fetus are in optimum health before going into labour .
  • Helps prepare the patient mentally and physically for labour
  • Every pregnant women should be encouraged to attend ANC

Assessment of Fetal Well-being


FETAL MONITORING 

Definition of fetal monitoring
 -  Method of assessing fetal status before and during labor

Why is fetal monitoring important?
To provide insight that may affect fetal outcome

ANTENATAL FETAL MONITORING

WHAT IS THE AIM OF MONITORING?


  • To decrease perinatal morbidity & mortality 
  • It should guide future care                                               
  • Reassurance
  • More frequent testing
  • Admission to hospital
  • Delivery 


WHICH PATIENTS ARE EXPECTED TO BENEFIT 
FROM THIS TESTING?


Patients at risk
  • IUGR
  • decrease fetal movement
  • Post-term pregnancy > 42 wk
  • Preeclampsia 
  • DM
  • Insulin requiring GD 
  • PPROM
  • stable abruption       

INTRAPARTUM FETAL MONITORING

WHAT ARE THE METHODS AVAILABLE FOR FETAL MONITORING IN LABOR? 

Electronic fetal heart monitoring --> External or internal
Intermittent auscultation 
Fetal scalp sampling --> pH determination
Color of the amniotic fluid

WHAT IS THE AIM OF MONITORING ?
To decrease the risk of intrapartum fetal asphyxia

  • Intrapartum fetal monitoring means simply to watch the fetal behaviour during labour.


Aim:

         To detect hypoxia and so prevent asphyxia which may cause either death or permanent neurological damage as cerebral palsy, mental deficiency or both.


ANTEPARTUM FETAL MONITORING
  • Two thirds of fetal deaths occur before the onset of labor.
  • Many antepartum deaths occur in women at risk for uteroplacental insufficiency.
  • Ideal test: allows intervention before fetal death or damage from asphyxia.
  • Preferable: treat disease process and allow fetus to go to term.



Methods for antepartum fetal assessment
  • Fetal movement counting
  • Assessment of uterine growth
  • Antepartum fetal heart rate testing
  • Biophysical profile
  • Doppler velocimetry



Fetal movement counting
Maternal perception of a decrease in fetal movements may be a sign of impending fetal death
3 movements in 30 minutes.
 10 fetal movements noticed in 10hrs or less, the fetus must probably is in good health


Assessment of uterine growth

General rule: Symphysofundal height in centimeters after 24 weeks till 36 weeks will equal the weeks of gestation.
Exceptions: maternal obesity, multiple gestation, polyhydramnios, abnormal fetal lie, oligohydramnios, low fetal station, and fetal growth restriction.
Abnormalities of fundal height should lead to further investigation.



Antepartum fetal heart rate testing

When to begin testing
Single factors with minimal to moderate increased risk for antepartum fetal death: 32 weeks.
Highest maternal risk factors: 26 weeks.


Which test to use?
Nonstress test
Contraction stress test
Low incidence of unexpected fetal death
Increase in time, cost and inconvenience
Biophysical profile, modified biophysical profile
Doppler velocimetry


Nonstress test (NST)

The nonstress test (NST) is performed by auscultation of the fetal heart rate using an electronic monitor.


  • Healthy fetuses display normal oscillations and fluctuations of the baseline FHR.
  • Absence of these patterns is associated with increase in neonatal depression and perinatal mortality.
  • Accelerations of the FHR during stress testing correlates with fetal well being .
  • Accelerations of the FHR occur with fetal movement, uterine contractions, or in response to external stimuli.
  • FHR accelerations appear to be a reflection of CNS alertness and activity.
  • Absence of FHR accelerations seems to depict CNS depression caused by hypoxia, drugs, fetal sleep, or congenital anomalies. 





Performing the NST
External monitors for contraction and FHR measurement applied.
Patient in left lateral tilt (to minimize supine hypotension).



Interpreting the NST

Reactive: 2 or more accelerations in 20 minutes.
Accelerations: an increase of at least 15 BPM above the baseline lasting at least 15 seconds.
Fetal stimulation by sound (vibroacaustic stimulation) may be used to elicit a response.

Interpreting the NST

Non reactive: Less than 2 accelerations in a 20-minute period.
May extend the testing period to 40 minutes or perform a back-up test.

Reactive/Nonreactive with decelerations: individualize management


Baseline FHR

Normal baseline FHR in a term fetus 37 completed weeks or more is 110-160 bpm.

Determination of the baseline FHR is done between contractions
Baseline is rounded in increments of 5 bpm example; if the FHR is running 125-135 then the baseline FHR should be documented as 130


FHR Pattern  

Baseline :
1.   Normal = 110 – 160 beats/min
2.   Tachycardia – Moderate 160 – 180 beats/min
3.   Severe > 180 beats/min 

4.   Bradycardia –  Moderate 100 – 110 beats/min
                              Severe < 100 beats/min

Variability:
Normal        > 5    beats/min
Reduced     3 – 5 beats/min
Absent        < 3    beats/min 


FHR Variability
  • Normal changes and fluctuations in the FHR over time. 
  • Best assessed between contractions
  • Considered to be the best indicator of fetal well-being
  • Variability can be influenced by hypoxic events, maternal hemodynamic issues, drugs, etc.



Examples of Variability

Absent: Not detectable from baseline
Minimal: Less than 5 bpm from baseline 
May occur with: 
normal fetal sleep patterns
mother has received analgesia for pain
Moderate : 6-25 bpm from baseline (optimal pattern)
Marked: More than 25 bpm from baseline


How Do Uterine Contractions Affect Fetal Heart Rate?  

Can affect FHR by increasing or decreasing the rate in association with any given contraction. 
3 primary mechanisms by which UCs can cause a decrease in FHR are by compression of
  •          Fetal head 
  •          Umbilical cord
  •          Uterine myometrial vessels 

    




Periodic and Episodic FHR Characteristics

Periodic: Refers to changes in the FHR that occur with or in relationship to contractions

Episodic: Refers to changes in the FHR that occur independent of contractions


Late Deceleration


Occur in response to utero-placental insufficiency. Blood flow to the fetus is compromised and there is less oxygen available to the fetus)



Prolonged Deceleration

  • Deceleration of the FHR from the baseline lasting more than 2 minutes but less than 10 minutes. 
  • No explanation for why these occur
  • Commonly associated with uterine hyperstimulation.
  • Can also occur without any uterine activity



Characteristics of Contractions

Frequency: How often they occur? They are timed from the beginning of a contraction to the beginning of the next contraction.
Regularity: Is the pattern rhythmic?
Duration: From beginning to end - How long does each contraction last?
Intensity: By palpation mild, moderate, or strong.
By IUPC (intra-uterine pressure catheters) intensity in mmHg
Subjectively: Patient description



Methods of Electronic Fetal Monitoring

External (cardiotocography)
Noninvasive method
Utilizes an ultrasonic transducer to monitor the fetal heart 
Utilizes the tocodynamometer (toco) to monitor uterine contraction pattern


Methods of Electronic Fetal Monitoring

Internal Fetal Monitoring

Invasive
FHR is monitored via a fetal scalp electrode
Uterine activity is monitored by an intrauterine pressure catheter (IUPC)


ANTEPARTUM FETAL MONITORING

Contraction stress test (CST)
  • Uterine contractions producing an intra-amniotic pressure in excess of 30 mm Hg, create an intra-myometrial pressure that exceeds mean intra-arterial pressure, therefore temporarily halting uterine blood flow.
  • A hypoxic fetus will manifest late decelerations.
  • Late decelerations correlate with stillbirth, IUGR, and low Apgar scores.
  • Oxytocin challenge test (OCT))
  • Breast (nipple) stimulation

  • How to perform the CST
External monitors for contraction and FHR measurement applied.
Patient in left lateral tilt (to minimize supine hypotension).
oxytocin infusion or breast stimulation.
Goal: three contractions in ten minutes.

  • Interpretation of the CST
Suspicious: Late decelerations are present with less than half of the contractions.
Hyperstimulation: Decelerations after contractions lasting more than 90 seconds
Unsatisfactory: Cannot induce adequate contractions or FHR recording is of poor quality.

Contraindications to CST

  • PROM
  • Previous classical cesarean delivery
  • Placenta previa
  • Incompetent cervix
  • History of premature labor in this pregnancy
  • Multiple gestation

Biophysical profile (BPP)

The BPP is another test for the evaluation of fetal well-being . It combines the NST with the observation by ultrasound of 4 variables:

  •  fetal breathing movements
  •  fetal body movements
  •  fetal tone
  •  amniotic fluid volume 

Each variable 
When normal: 2
When abnormal: 0
Highest Score: 10, Lowest Score: 0
Accuracy improved by increasing the number of variables assessed.
Overall false negative rate: 0.6/1000

Fetal tone: 7.5 to 8.5 weeks
Fetal movement: 9 weeks
Fetal breathing: 20 to 21 weeks
NST: 24 to 28 weeks


Modified Biophysical Profile

The MBBP is an excellent test for evaluation of the fetal well being. 

Start  NST in standard manner. If a spontaneous acceleration not seen within 5 min, a single1-2sec, sound stimulation is applied in the lower abdomen with the artificial larynx. This stimulus may be repeated up to three times if necessary.  

A four quadrant amniotic fluid volume is assessed by placing an ultrasound transducer perpendicular to the wall of the uterus in four abdominal quadrants and measuring the largest vertical amniotic fluid pocket. A four-quadrant sum of 5 cm or greater is considered normal.

Doppler velocimetry
     
The  use of  Doppler ultrasound for the evaluation of the fetal circulation is based on the physical principle of change in frequency of a sound wave when it is reflected by a moving object. During Doppler studies fetal and maternal vessels are interrogated with ultrasound waves .

    
The Doppler frequency shift caused by the moving red cells is submitted to spectrographic analysis and represented graphically as a waveform. These waveforms represent  changes in the velocity of the blood flowing through the vessels.                                           


  • Doppler velocimetry


A poor indicator of fetal compromise or adaptation to the placental abnormality but does identify patients at risk for increased perinatal mortality.
Strong association between high systolic to diastolic ratios and IUGR.


  • Doppler velocimetry


An increase in the vascular resistance of the fetoplacental unit leads to a decrease in end diastolic flow velocity or its absence in the flow velocity waveform.
Abnormal waveforms reflect the presence of a structural placental lesion.
Abnormal Doppler results require specific management protocols and intensive fetal surveillance.



Uses : plays a vital role in the diagnosis of fetal cardiac defects .
assessment of the hemodynamic responses to fetal hypoxia and anemia. 
diagnosis of other  non-cardiac malformations. 



Doppler velocimetry of the umbilical arteries

40% of combined ventricular output is directed to the placenta by umbilical arteries.
Assessment of umbilical blood flow provides information on blood perfusion of the fetoplacental unit.
Low vascular impedance allows a continuous forward blood flow throughout the cardiac cycle


Basic Principals


The volume flow in the UAs increases with advancing gestation. The high detected in the first trimestvascular impedance er gradually decreases. It is attributed to growth of placental unit and increase in the number of the functioning vascular channels.

 

UMBILICAL ARTERY FLOW 

characteristic saw-tooth appearance of arterial flow in one direction and continuous umbilical venous blood flow in the other. 



Umbilical artery

  • With advancing gestation, umbilical arterial Doppler waveforms demonstrate a progressive rise in the end-diastolic velocity and a decrease in the pulsatility index. 

  • Absent end diastolic flow in the UA wave forms obtain by Doppler ultrasound  is important  evidence of fetal compromise and demands frequent  and intensive fetal surveillance .

  • Reversed end diastolic  flow in the UA is a sign that is shortly followed by fetal demise. Fetuses with reversed end diastolic flow in the UA are acidotic and required prompt delivery.

Uterine artery Doppler
  • Doppler  interrogation of the uterine arteries is usualy performed with transabdominal ultrasound .
  • An important variable in the interpretation of uterine artery Doppler is the gestational age at the time the test is performed.



  • Test is done before 20 weeks of gestation, the no. of false positive results is high, after 24 weeks, trophoblastic invasion has ended and false positive results will decrease.



  • Abnormal uterine artery doppler wave forms indicate increase resistence in the maternal side of the placenta and their main use is as a screening tool for preeclampsia.